I had a similar experience to yours - bought a small PJB combo, liked what it did and decided to try a full rig.
You can certainly do it, but it won't be cheap. They will deal with fat tones happily, but you'll need a few of those small drivers to shift enough air in a live situation. The good news is that they often come up used and, as they are often bought by jazzers and non-headbangers, they are usually in good shape and have not been caned.
They cut through very well on stage in my experience. However, I am playing in a soul band and doing functions, pubs and clubs. I am not competing with heavy-handed drummers or guitar players. Your situation may be different.
They also project well into a room. I used to play in the house band at a local jam night and it surprised me how well my two PJB 4x5 cabs filled the space when I listened to others playing.
If you want to make a bit of noise, especially with fat, low-end heavy tones, you will need a few drivers as I mention above. I have five 4x5 PJB cabs and run three or more of them when I want to shift some air. They are inefficient, so you will need powerful amplification. If you buy the PJB powered cabs, that will be taken care of, but if not, you need at least 250W per 4x5 cab to get them singing.
I'm not so keen on PJB amps. I find them a bit too hi-fi. I use Aguilar and/or Carvin amps, plus a PA power amp if needed, which give me the warmer, more old-school tone I prefer.