I run mine pretty much flat but dial back/cut the treble a tad as it's a very bright head. Then I may engage the bump for a touch more low end if required. Alternatively, experiment with boosting the low mid to e.g. 2pm and bass to e.g. 1pm and see which you prefer.
I don't really use the overdrive but if I do I keep it very low for just a little growl and then use the edge to control how bright it sounds.
It's a great amp with tons of power through an efficient 8ohm or 4 ohm cab. Cabs colour amps as well so I find that it sounds full, punchy and tight through my Genz 2x12 4ohm cab, and clear, punchy and more piano-tone-like through my LFSys Monaco 8ohm 1x12 cab. I have to dial the treble right back with the latter cab!
Play around with it, try the switches and then disengage them and try adjusting the EQ in a similar fashion.... see which you prefer. It's a very responsive head! Enjoy!