Middly drive and bit clean lows is the way. Problem is most rives are scooped, and low cut for chugging guitars and sounding good on its own. I used Sansamp into valve amps for a pretty big sound. Wasn't super defined, but tuning to A will do that for you, I reckon I can get much more definition and the same size with my newer rig that is half guitar stuff, much more middle there.