As longs as the nut is cut, and the setup is done, no probs at all. I play 4 strings tuned ADGC with strings from .145 to .070, not sure of the inbetween 2,might be good to keep the old nut as is, and get a new one to make big slots in. I think the Dark Lord strings are taped, so saddle raising might be needed, no biggie.