It's nearly 20 years since I used a 'stack' (Trace 2103H on top of an 1153 powered by an AH150) and TBH, I couldn't see what all the fuss was about. Yes, it looked amazing on stage, but I remember (even as a 20 year old) it being a ball ache to lug around. If your chiropractor, significant other, and finances have no sensible objections then go for it. I'm currently on the single 4x10 wagon and it's got more than enough poke to keep up with a metal drummer and 2 guitarists with 100W valve stacks and 4x12s.
For videos and suchlike I'll probably hire in another cab to perpetuate the myth that we all need a massive stack, but in reality when we were recording new material last week I didn't even use it…
Edit: Guitarists use 4x[b]12[/b] cabinets, not tens...