In the full fat helix / LT / rack you can split 4 paths if you want. EQ / compress / whatever them all separately and even send them to 4 separate outputs (2 XLR and 2 1/4) as well. Or combine them.
I like running the B7K model without a cab at all, but with a parametric EQ, in parallel with a Rat into a GK amp with a cab, and then a third underneath being the brand new SVT4-pro model for deep low cleans.
And then with the beauty of Snapshots I can change multiple parameters on everything with just 1 press of a footswitch.