IME you just have to get used to your system. For example, my monitors at home are not great. They're too bright and lack bass. I use the EQ on my little mixer to compensate somewhat, but basically I know that if it sounds a bit harsh in the highs on my system, it'll sound allright on most other systems.
I added a sub to compensate for the lack of bass, which really works for me, but I've been told by pros that this is an absolute no-no