[quote name='Oscar South' post='194372' date='May 8 2008, 03:54 AM']Interesting to see that a few people run their comp after distortion, I read or was told a while back that its much less effective that way as its much harder to compress a distorted signal than a clean one (something to do with all the extra overtones the distortion creates or something).[/quote]
I wouldn't know about overtones but...
If you distort a signal, you are clipping the peaks. This is basically a really harsh form of limiting, so (depending on your amount of OD/fuzz) you loose a lot of your dynamic range, which is quite like using a compressor or limiter. Distortion before compression means that your playing dynamics can still fully react with the dirt pedal, while the compressor does whatever you've set it to do.