With mine, I have one simple "basic good sound" patch that I always start with. This is what I use when I'm practicing or just using it as an interface for recording. This stops me spending hours tweaking when I should be working on something else.
The tweaking for me comes when I have a function/wedding set list to get together. For instance, we were asked for Pink Pony Club on a set, and I was able to get pretty close to the original bass synth sound with some funky routing. That just sits on a preset now for whenever I need it, without having to worry about adding/removing pedals or doing some sort of tap dance to get everything in place