Yes I use it. It isn't without its limitations - but then all pedals have those.
I have to say it remains the easiest pedal to set up without recourse to a computer or tablet. It has fantastic effects and a couple I feel could be better - specifically the octave up and pitch shifts can be wobbly and pitchy.
The touch screen is great, the overdrives, fuzzes, filters, modulation, compression and amps sound great. Don't use the cab sims so can't say.
I've finally got the software to work on the PC and it's fine, intuitive.
I owned the Helix and I don't know if the Ampero is definitively better, because personal taste comes into it so much.
I've gigged with it as part of a pedal board and as a standalone. It's great as a stomp with the additional 2 button footswitch.
I think it's great, but I haven't used it as much as other people might have because I'm a pedal board butterfly and keep changing up.