Now I'm an amateur and stand to be corrected but my experience is that the particular venue/room makes most difference whatever cab you use.
At one particular WMC with a very high ceiling, (I think it's called the Harold Wilson Labour Club in Cradley in the Black Country), it was so difficult to get a good overall sound. I think the reverberation time for the room must have been several seconds.
Down the road at another WMC the stage was so boomy, that along with hiss picked up by any guitar without humbuckers i.e. Strat's, from the tube lights over the stage.
My routine would be to move around the stage listening and tweak my amp controls to get 'my sound' in the mix. But that's the on stage sound of course.
If I had someone out front with trusted ears I might ask if the balance was OK.
Sometimes I might go FOH and ask another band member to play my bass.
So setting up and doing the mixer/PA got me interested in acoustics and I read up a fair bit. But learning about and good practice only comes with experience and developing 'good ears'. Sadly now mine are cream-crackered.
As for what cab well, since getting my 2 BF One10s I'm sorted for the rest of my days.