I don't gig on guitar because I'm still learning.  However I have the following favourite patches: 
[list] 
[*]Joe Satriani patch with Marshall-ish feedbacking distortion, delay, wah and chorus 
[*]Nile Rodgers patch with clean Fender-ish sound and wah 
[*]David Gilmour patch with clean Fender-ish sound, flanger and multi tap delay. 
[*]Andy Summers patch with clearn Fenderish sound, reverb, flanger and slap back delay. 
[*]The Edge patch with clean vox-ish sound, and multiple stereo ping-pong delays. 
[/list] 
Plus a generic rawk overdrive patch for crunchy power chords.