Mind ya, I have no experience to talk about, but FWiW:
Ashdown Little Bastard 30 + two LB 112 cabs
for velvety but still well defined old skool sound
Genz Benz GBE 750, for the time being with those same Ashdown cabs
for large, detailed, transient-willing, airy (headroomy) sound - plus for added overdrive noise if I want to.
That said, I expect a lot from the GBE with the Vanderkleys and Barefaceds I'm getting later.