If you're not used to it, take the low B off to begin with and play your regular material with it first. Think of it like a 4+1 rather than a 5'er to begin with.
Cheers Chunky - actually it's gojng better than I thought! What works for me is to play familiar lines whilst looking at my right hand to better gauge the string spacing. It's a lovely budget 2nd hand Ibanez SRX505, only issue is the string spacing is quite narrow for me (7mm at nut) .