I tried lightweight gear years back and gradually made my way back on heads to heavier, more traditional designs.
I mainly use a Mesa 400+ and my MJW Taranis, which is like a highly pimped GT200. For cabs, the big Barefaced do it for me, super light for their size and match up well with big valve amps. The BF cabs make handling a big cab easy and as for heavy heads then since I'm the bass player, there's always someone to help carry stuff.
If I was a solo artist that would be different but I play in a five piece rock band.
Out of interest, I always carry a Markbass Nano in my gigbag as backup but that's because it's easy to tuck away as an emergency spare.
So, what I'm saying is, go with what sounds good to you and get someone to help you carry gear or get a trolley.