What Ω are your cabs each?
You never said in the post & everyone's assuming that they're both 8Ω. If one is 8Ω & the other is 4Ω, then that makes 2.66Ω, which could damage your amp. If they're both 4Ω cabs, then that's gonna be a 2Ω load
Given the choice & if I liked the sound of the 1x15, I'd have went for a 2nd 1x15 & made a 2x15 rig (better dispersion than the 4x10). If you prefer the sound of the 4x10, then get a 2nd 4x10 if you need more.
A 2x10 in your set up means that 2 drivers are gonna be running twice as hard as the other 4 (this is if all cabs are 8Ω).
Your way around it is if you have a 4Ω 4x10 & an 8Ω 2x10, but your amp may not handle this.