Ed_S pretty much nailed it.
I'm in a thrash metal band, using a 5 string tuned AEADG.
Where I used a 412 cab for a decade, a modern 2x12 (I found a b-stock darkglass) turned to be a capable alternative. Compression, tuner and dirt from pedals, I use the DI in my amp to send the signal to the desk.
A hybrid or solid state amp of more than 400 Watt, or 200 tube Watts should see you through most scenarios.
If it doesn't have to be brand new, have a look at the For Sale section here.