We play in dropped tuning - D#, which puts slightly less stress on our aging vocal chords. Then with my Hipshot d-tuner I drop down to C# for a few songs. I'm using D'Addario pro steels with a 105 E string and have no problems - sounds great and string still has decent tension on it. Oh, and 34" scale
Edit to say it's the standard 45-105 set. Caveat: I don't drop the other strings to C# tuning, just the E