Absolutely! - And, as we are seeing with everyone throwing in high pass filters to remove the stodge from their sound and boosting the mids to 'cut through the mix, often just opting for a guitar type cabinet will suffice. Yup, using the ears instead of the eyes to, as you say, give the right tone for a particular setting, song or environment. Interestingly, I have added a cab sim to one of my chains but as yet it has remained off. So, for me, no amp or cab time in there at all.