I've tried this with the Line 6 system, with the Smoothound unit, and with wireless bugs (X-vive, Joyo, Lekato).
When they work they all sound exactly the same - as you'd expect. The Line 6 was the most 'stable' once in position, i.e. the least likely to give connectivity issues, but was far and away the most additional faff at a gig that I really didn't need, especially since almost all my DB gigs are doubling gigs. The Line 6 requires the most extra kit, the most pluggery, the most extra options to trip you up just before the start of set #1.
I have a Line 6 unit in perfect nick in a protective case safely gathering dust in my studio. Haven't used it in several years.
All the 'bug' systems (and that includes for these purposes the Smoothound) are far easier to use and have far less to go wrong. The Smoothound requires a plugged-in base station with very fragile antennae so I sold mine. The expensive X-vive and the cheap Joyo/Lekato (basically the same units but badged differently) are indistinguishable in use at a gig but share one common but intermittent problem ... they seem sensitive to the combination of vibration + angle of dangle which can produce a sort of juddering cutting out when you're pushing hard. The angle at which you have the main bug to the jack going into the socket - these are usually hinged units, remember - can encourage or damp down this vibration, but whatever angle you start at can change during the gig as gravity does its thing.
For this reason I now use only https://www.amazon.co.uk/JOYO-Wireless-Transmitter-Receiver-Instruments/dp for DB, whilst continuing to use X-vive and Joyo bugs for electric bass.
The fact that the bug holder is also a recharging unit can be an absolute life-saver if you're gigging intensively.