You feel a bit 'detached' at first, but you quickly get used to that.
What I found unacceptable was the amount of faffing about that was involved with routing the cables where they don't get in the way of you or your bass, plus taking off and putting on the bass. Doesn't sound like much, but if you're used to putting your bass down for a minute while you take a close look at the PA settings or whatever, it quickly becomes an issue.
Reading your original post, it might make more sense to buy a more general-purpose unit that can offer solutions to a bunch of different problems, including some you may not yet have bumped into.
I have a Studiomaster PAX12 powered wedge. Essentially, it's a simple single-box mono PA. At different crisis points in my gigging life, it has been used as a vocal PA, a guitar combo, a bass rig, a foldback monitor, and the main output for a set of Roland electronic drums. It's a classic Jack-of-all-trades unit, and remarkably competent at all of them.