First impressions without trying to play it through.
1) What's the tempo?
2) Is there some pattern that repeats itself over the parts? I am not able to see anything like that, yet, but most likely I should play it through first.
3) Done by a machine (see the first notes in bar 15)? How does it sound straight from the computer?
4) What kind of band is playing? Is it even possible to go up high if there are keys close by? Soundwise it may be feasible to stay in the half and first position.
5) I think (this is my very biased opinion) that bass should be rhythmic instrument in modern music. Compared to say baroque music I believe melodic content was more important then than rhythmic if we look at older and today's music. Therefore many melodic jumps seen in the score might be possible to "reduce" to smaller intervals without "reducing" rhythmic content. Ghost notes should not be forgotten.
Wishing to see comments from the pros here, like TKenrick, Bilbo, Tom Read, Chris Dev, et al.