I set up all my own basses, most of them have recut nuts. I like a low action. But when the action in the shop is around 6mm at the 12th fret you can't make any sort of connection.
FWIW I tried out a brand new Aerodyne (MIJ) with an eye to purchase, but the setup was horrible and I couldn't bond with it.
OTOH my Squier 40th P (MIC) was set up to (near) perfection.
Shouldn't be an issue with uneven spacing as the end holes ought to be ok and its probably just careless setup.
I agree that overall bridge alignment out by more than one or two threads is likely problematic.
I enjoy the physicality of playing with my fingers, particularly the way I can use fingers an thumb to mute and make different effects I vould never do with a pick.
Pick suits some styles and songs though.
It depends on what language you are speaking. In Welsh and French, for example, all objects are gendered.
English's supposedly lost this with Middle English, but in practice it's hung on and been influenced by languages like French.