I've had to move my 'office' into my workshop.
This is good as it means I have my TE combo set up and switched on all day and, presently, a jazz bass in reach from my chair.
I have input gain nice and high, the pre-shape in, balanced by a gentle 3db lift centred on about 2kHz, usually no effects.
I find I can spend ages just playing simple riffs or just single notes, especially on my Jazz where playing with the volumes (I generally leave the tone right up unless playing reggae) and moving my playing position gives me a huge range of wonderful sounds.
I am very, very happy with the tones I am getting.