Tuner on the way to the amp... as sometimes you can select a mute...
Effects usually in the loop..
Try say the distortion on its own before the amp, then in the loop...
Usually EQ, Sound Filters Distortion, Then Modulation Phaser Flanger, Then Time Reverb and Delay...
but with a delay, do you want the echos to sound the same? or try a modulation phaser or flanger after the delay, then the echoes will be different...
If anything is Stereo you can split up the routing...