I suppose the next question would be, do you need amp/cab modelling, or just effects?
If you're just wanting effects into your amp, then it would be the HX FX every time.
If you do want amp/cab modelling, then you need to ask yourself more questions. How many effects do you need at one time? More than 3 per song, then the POD Go is out (have one myself, it's great, but limited). There are work-arounds, likes switching between patches/presets.
The HX Stomp / Stomp XL have most of the functionality of the Helix, but not the footswitches or connectivity. Loads of options though, parallel signal paths and lots of other goodies. Sure a HX/Helix user will be along to fill in the plus points.
Don't know much about the B6, but it'll have plenty of effects as well as amp/cab models, so loads to choose from.
Having been down the pedal board rabbit hole with guitar effects, it is a hit or miss affair, which can end up with serious serial pedal purchasing just trying to find the right pedals that work for you. Great fun, but a complete money pit, and you end up with a ton of pedals, associated boxes and other paraphernalia kicking about.