There is no right answer to this thread , but i believe firstly you must know your songs well and have own default tone.
After this what is wrong with either having fun replicating sounds or reinventing depending on your personal and bands desires, or just sticking to your own sound all through , That's just 3 possible routes and id enjoy a band doing any of them well.
I love playing effects, I can do picked overdrive Stranglers type sound then do 80s fretless to bright compressed 80s pop lines.