I find that the only way I can stay motivated to "practice" often is just to play through songs I know and enjoy playing. I have a variety of songs on an Amazon Music playlist that I add to whenever I learn something new. I will often only play for around 10 minutes, but sometimes I end up doing this several times a day whenever I get bored of what I am supposed to be doing! It seems to be working as I see an improvement when I go back to songs I haven't played for a while.
Equipment wise, I generally play through my Ashdown Studio 12 combo, with headphones if necessary but without if no-one else is in the house! That way I can use my pedals and the overdrive in the amp. If I need to go to a different room, I use my Amplug headphone amp instead.