It really depends on your budget, and what sort of music you'd be playing...you don't want to be struggling to be heard obviously.
If you've got a good budget then I'd be looking at one of the lightweight 212 cabs from say Bergantino, TKS, Barefaced etc combined with a lightweight head.
If however you're a bit more money conscious (like me ), then for a lightweight combo that doesn't cost a lot either it's hard to beat the Fender Rumble 500 v3. Lovely tone, holds its own volume wise in all but the loudest bands, even then you can add another cab and blow your bandmates through buildings. Great little combos...