To be fair, for most people, especially on bass, once you have your killer amp sound, you are unlikely to be changing much. On a gig, I have my core sound - easily tweakable per venue... and then fx in the fx slots.
In reality, the tweaking factor is not an issue for me - as I am on IEMs. So any tweaking should be at the PA to account for the room, nothing else. I haven't got a local FRFR that I'm using for monitoring purposes - just front of house.